Dedicated to Patients Presenting with Metastatic Cancer Whose Primary Site Remains Ambiguous
Welcome to Cancers of Unknown Primary Site [CUP]. In the following pages both patients and clinicians may read about the history and evolution of one of the most difficult diagnostic challenges facing oncologists- Cancer of Unknown Primary Site.
This website attempts how to best define the clinical entity known as CUP, i.e., those patients who present with advanced cancers and the origin of the cancer is uncertain. The diagnostic odyssey imposed on CUP patients is discussed as are the varied clinical presentations. The evolution of pathology from from hematoxylin and Eosin [H&E] stains to immunohistochemistry [IHC] and gene expression profile [GEP] is covered with examples as to how this new technology may provide valuable insight into identification of the primary cancer site [cell of origin]. In addition how these newer technologies offer promising insights into more focused treatment plans are discussed.
The site is intended for both the clinician and the patients and families who wish to know more about this entity- CUP. Your participation by providing clinical data on specific cases is welcomed and a major feature of this website.
The authors apologize for the web site as it is being developed. Over the next few weeks the site should be completed. If any one has suggestions for improvement please contact us with your ideas.